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Sclerotherapy and Foam Sclerotherapy are established methods of treating smaller leg veins that use microinjections of a sclerosing solution. The solution is injected into the vein, causing it to collapse and fade away. The treatment generally requires 3 to 6 sessions for optimal and permanent results. While sclerotherapy cannot stop new spider veins from appearing, it can eliminate treated veins. Sadick Dermatology Fast Facts: Results observed after 6-12 weeks. Requires 3-6 treatment sessions, performed one week apart. Patient may experience itching and slight burning sensation for 1-2 hours following treatment. .