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Recent advancements in technologies and support from major aesthetic companies have encouraged off-face rejuvenation. The most prominent off–face areas for rejuvenation includes: neck, chest, hands, arms and legs. With most patients that have experienced the remarkable rejuvenation capabilities of our treatments, it is a natural next step to establish programs to improve the appearance of these off-face areas. These treatments are usually multi-faceted approaches to anti-aging that may include multiple laser and light source devices, fillers and injectables. Sadick Dermatology and the Sadick Research Group in partnership with major aesthetic companies have worked together to establish new protocols and treatment paradigms for off-face rejuvenation. Our most prominent work has been on the hands, where we have conducted numerous treatments to improve the appearance of aging hands.